Using New Lung Imaging and Biologic Markers to Improve Radiotherapy for Lung Cancer

Single-arm prospective interventional study assessing feasibility of using gallium-68 ventilation and perfusion PET/CT to avoid functional lung in patients with stage III non-small cell lung cancer

N Bucknell, N Hardcastle, P Jackson, M Hofman, J Callahan, P Eu, A Iravani, R Lawrence, O Martin, M Bressel, B Woon, B Blyth, M MacManus, K Byrne, D Steinfort, T Kron, G Hanna, D Ball, S Siva

2020-12-10

Background In the curative-intent treatment of locally advanced lung cancer, significant morbidity and mortality can result from t..

Correlation of positron emission tomography ventilation-perfusion matching with CT densitometry in severe emphysema

A Bonney, CA Wagner, S Siva, J Callahan, PY Le Roux, DM Pascoe, L Irving, MS Hofman, DP Steinfort

2020-01-01

Background: Emphysema severity is frequently measured on CT via densitometry. Correlation with scintigraphic and spirometric funct..

PET-detected pneumonitis following curative-intent chemoradiation in non-small cell lung cancer (NSCLC): recognizing patterns and assessing the impact on the predictive ability of FDG-PET/CT response assessment

A Iravani, GA Turgeon, T Akhurst, JW Callahan, M Bressel, SJ Everitt, S Siva, MS Hofman, RJ Hicks, DL Ball, MP Mac Manus

2019-08-01

Purpose: Inflammatory FDG uptake in the lung (PET-pneumonitis) following curative-intent radiotherapy (RT)/chemo-RT (CRT) in non-s..

Radiation Therapy Modulates DNA Repair Efficiency in Peripheral Blood Mononuclear Cells of Patients With Non-Small Cell Lung Cancer

X Yin, J Mason, PN Lobachevsky, L Munforte, L Selbie, DL Ball, RF Martin, T Leong, S Siva, OA Martin

2019-02-01

Purpose: There is growing interest in developing individually tailored cancer radiation therapy (RT), wherein patients with high i..

Automatic delineation of functional lung volumes with 68Ga-ventilation/perfusion PET/CT

PY Le Roux, S Siva, J Callahan, Y Claudic, D Bourhis, DP Steinfort, RJ Hicks, MS Hofman

2017-01-01

Background: Functional volumes computed from ⁶⁸Ga-ventilation/perfusion (V/Q) PET/CT, which we have shown to correlate ..

Estimating lung ventilation directly from 4D CT Hounsfield unit values

J Kipritidis, MS Hofman, S Siva, J Callahan, PY Le Roux, HC Woodruff, WB Counter, PJ Keall

2016-01-01

Purpose: Computed tomography ventilation imaging (CTVI) aims to visualize air-volume changes in the lung by quantifying respirator..